Erlotinib Hydrochloride CAS 183319-69-9 Chemical Intermediates

Product Description:

Product Name: Erlotinib hydrochloride CAS NO: 183319-69-9                                        

Synonyms:

N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride;

Tarceva;

OSI 774;

Chemical & Physical Properties:

Appearance: White or off-white powder

Assay :≥98.0%

Boiling Point: 553.6℃ at 760 mmHg

Melting Point: 223-225℃

Flash Point: 288.6℃

Vapor Pressure: 4.52E-12mmHg at 25℃

Storage Temp.: -20℃ Freezer

Safety Information:

HS Code: 2933990090

Erlotinib hydrochlorate is a small molecule tyrosine kinase inhibitor which acts reversibly on epidermal growth factor receptors, a hydrochloride of erlotinib, a molecular-targeted drug. The US Food and Drug Administration (FDA) has approved erlotinib (Tarceva) combined with gemcitabine as a first-line treatment for locally advanced and metastatic pancreatic cancer.

It is mainly used as a second- or third-line treatment for locally advanced or metstatic non-small cell lung cancer (NSCLC) and as a treatment for pancreatic cancer. It is used as a tyrosine inhibitor for NSCLC treatment.

Erlotinib hydrochloride (V), a quinazoline derived small molecule inhibitor of epidermal growth factor receptor (EDGFR) tyrosine kinase, was approved in November, 2004, for the treatment of advanced or metastatic non-smallcell lung cancer. It belongs to the same class as gefitinib,another quinazoline approved for treatment of advanced lung cancer, but with improved pharmacokinetic properties. The molecule was originated by Pfizer and development initiated in collaboration with OSI, which assumed full rights to the drug when Pfizer merged with Warner Lambert. Subsequently, Genentech/Roche went into licensing agreement with OSI to develop and market the drug in the US and Worldwide.

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